奥扎格雷钠对脑梗死血液流变学的影响

Effect of Sodium Ozagrel on Blood Rheological Property of Patients with Cerebral Infarction

目的 :探讨脑梗死与血液流变学异常之间的关系及奥扎格雷钠对异常血液流变学的影响。方法 :奥扎格雷钠 80 0mg加入 5 %葡萄糖或Ringer液 5 0 0ml静脉滴注 ,每天 2次 ,疗程 2周。患者于治疗前后分别采用LBY N6型旋转式粘度计 ,以温氏法检测血液流变性 ;采用国产MCAS 2 0 11型微循环图像测量分析系统 ,根据“甲襞微循环综合定量评价方法”对微血管形态、微血流流态及袢周状态进行测量与评分。结果 :5 6例脑梗死患者治疗前全血粘度、血浆粘度、红细胞压积及红细胞聚集指数明显增高 ,甲襞微循环障碍 ;治疗后上述指标不同程度得到明显改善 ,与治疗前比较 ,差异有显著性。结论 :奥扎格雷钠具有改善血液流变性、改善微循环障碍及降低血液粘度的作用 ,而血液流变性不仅可用来阐述脑梗死的发病机理 ,而且是指导治疗、判定药物疗效及疾病预后的重要参数之一。

Objective: To explore the relation between cerebral infarction and change of blood rheological property and the effect of sodium ozagrel on blood rehlogy property of patients with cerebral infarction. Methods: 56 patients with cerebral infarction were treated with sodium ozagrel intravenously for 2 weeks, 80 mg every day. The changes of blood rheological property and nail wall microcirculation in all patients before and after treatment were observed. Results: Whole blood viscosity, plasma viscosity, packed cell volume and index of erythrocyte aggregation were obviously increased before treatment, but decreased after treatment. There was statistically significant difference. Conclusion: Sodium ozagrel could improve blood rheological property, nail wall microcirculation and reduce blood viscosity. The measurement of blood rheological property is a major method to study cerebrovascular diseases and evaluate therapeutic effect.