菲立磁增强MR不同序列对肝脏病变的对比研究

Comparison between Different Sequences of Feridex-enhanced and rutine MRI for the Detection of focal Hepatic lesions

目的:探讨菲立磁在肝脏占位性病变诊断中的应用价值。方法:对17例肝脏占位性病变的患者,行MR平扫和菲立磁增强MRI检查,扫描序列为T2W/TSE、T1W/SE、T2FS/TSE和T2W/FFE、T1W/FFE,比较增强前后肝脏的信噪比(SNRN)和病灶信噪比(SNRM)及发现病灶的数量、形态。结果:菲立磁增强后五个序列的肝脏信号强度均较平扫明显下降(P<0.01),T2W/TSE、T2FS/TSE、T2W/FFE肝脏信号强度下降程度较为显著;但病变的信号强度变化不大(P>0.05)。结论:菲立磁增强T2W/TSE,T2FS/TSE、T2W/FFE可明显提高肝脏占位性病变的检出率,T1W/SE和T1W/FFE在肝脏局灶性病变的定性诊断中具有潜在价值。

Objective:To evaluate Feridex(superparamagnetic iron oxide,SPIO)enhanced MRI in the diagnosis of focal hepatic lesions.Methods:Routine and Feridex-enhanced MRI were performed in17patients with suspected focal hepatic lesions.The pulse sequences of Feridex included:T 2 W/TSE,T 1 W/SE,T 2 FS /TSE,T 2 W/FFE,T 1 W/FFE.The effects of Feridex on signal intensity,SNR m of lesion vs normal hepatic tissue were assessed with quantitative analysis.Results:Compared with routine scanning,the signal intensity of liver on Feridex-enhanced MRI was significantly decreased while the signal intensity of lesions showed no marked changes.Conclusion:The detection of focal hepatic lesions can be significantly im-proved with Feridex-enhanced T 2 W/TSE,T 2 FS /TSE,T 2 W/FFE,which has potential values for qualitative diagnosis of such lesions.