维生素E对糖尿病患者肾脏的保护作用

The protection of Vitamin E on patients with type 2 diabetic nephropathy

目的:探讨维生素E对糖尿病患者肾脏的保护作用。方法:将146例2型糖尿病患者随机分为糖尿病维生素E治疗组(A组)和糖尿病对照组(B组),根据24h尿白蛋白排泄率(UAER)水平再将A、B两组各分为两个亚组,UAER<20μg/min为A1、B1组,UAER为20～200μg/min为A2、B2组。并测量血、尿肌酐、血糖、糖化血红蛋白、胆固醇、血脂和Alb/Cr。结果:各组治疗前后组内、组间比较,6月后各项指标均无统计学意义;但治疗12月后,A1和A2组内比较,肾功能指标UAER、尿白蛋白与尿肌酐比值(Alb/Cr)、Ccr均有统计学意义(P<0.05或P<0.01)。A1和B1、A2和B2,UAER、Alb/Cr、Ccr差异均有显著性,且HDL-Ch升高(P<0.05或P<0.01)。结论:糖尿病患者长期服用维生素E可有效地降低UAER、Alb/Cr及Ccr,对其肾脏功能有一定保护作用。

Objective:To investigate the renal protection of Vitamin E on patients with type2diabetes mellitus.Methods:One hundred and forth-six cases type2diabetic patients were studied and di-vided into group A and group B,randomly,and group A were treated with Vitamin E.In addition,accord-ing to the urine albumin excretion(UAER),the patients were subdivided into two groups,A1group or B1group(UAER<20μg /min),A2group or B2group(UAER20～200μg /min).The levels of serum crea-tinine,urine creatinine,UAER,HbA1c,triglyceride,cholesterol and Alb /Cr were determined.Results:At the6th month,no change of above indices was observed among4subdivided groups.While at the12th month,the levels of UAER,Alb /Cr,Ccr in group A2were significantly higher than that in group A1(P<0.05or P<0.01).but UAER,Alb /Cr,Ccr in group A1or A2was significantly lower than that in group B1or B2(P<0.05or P<0.01).At the level of 12months,HDL-Ch was significantly higher in group A2than that in group B2.Conclusion:A long-term treatment with vitamin E can partially protect renal function of diabetic patients through reducing UAER,Alb /Cr,Ccr.