对肾性贫血血液透析患者补铁疗效的临床观察

Clinical Observation of Efficacy and Safety of Polysaccharide Iron Compound on Hemodialysed Patients of Chronic Renal Failure with Iron Deficiency Anemia

目的:比较多糖铁复合物(PIC)与硫酸亚铁两种铁剂对纠正CRF透析合并缺铁的疗效及安全性。方法:选择用促红细胞生成素(ERO)治疗的肾性贫血的慢性肾衰透析患者79例,随机分为观察组(多糖铁复合物组)与对照组(硫酸亚铁组),3个月为1疗程。观察疗效及治疗期间可能产生的不良反应。结果:PIC组总有效率达91.7％,优于硫酸亚铁组87.5％(P<0.01),并且其副作用发生率远远低于硫酸亚铁。结论:口服PIC对纠正缺铁是一种安全、有效,且毒副反应小的药物。

Objective:To compare the efficacy and safety of polysaccharide iron compound (PIC) with that of ferrous sulfate(FS) for treating heraodialysed patients of chronic renal failure (CRF) combined with iron deficiency anemia. Method: 79 patients, divided into two groups randomly, were given PIC and FS respectively. Hematology assay was performed and the adverse effects were monitored. Results: The efficacy of PIC(94.1%) was better than that of FS(87.5%) and the occurence of the side effect of PIC was less than that of FS. Conclusions: PIC is an effective and safe drug for treating the patient of CRF combined with iron deficiency anemia.