脑肿瘤后程超分割放射治疗的临床研究

Late Course Hyperfractionation Radiotherapy for Brain Tumors

目的 :评价后程超分割放射治疗脑肿瘤的疗效。方法 :对 30例脑肿瘤术后患者进行后程超分割放射治疗 (常规放疗至DT30～ 4 0Gy后 ,按 1 2Gy/次 ,2次 /天 ,间隔 6小时以上进行照射 ,总剂量 6 0Gy) ,与同期 30例采用常规分割放射治疗的脑肿瘤病人作为对照组 (照射方法为 2 0 0cGy/次 ,1次 /天 ,总剂量 5 0～ 5 6Gy/ 2 5～ 30次 / 5～ 6周 )进行 1、3、5年生存率的比较。结果 :后程超分割组与常规分割组的 1、3、5年生存率分别为 6 3%、31%、11%和 5 3%、4 0 3%、2 0 % ,2组无显著性差异(P >0 0 5 )。结论

Objective:To evaluate the therapeutic effect of the late course hyperfractionation radiotherapy for brain tumors.Methods:Thirty patients with brain tumors after operation received the late course hyperfractionation radiotherapy(LCHR) for brain tumors(when the convention fractionation radiotherapy reached D T30～40Gy/15～20fs/5～6wks,they were fixed at 1.2Gy twice daily with a minimum interfraction interval of 6 hours,5 days perweek,D T60Gy)While in the 30 patients of convention fractionation radiotherapy(CFR),receive a total dose of 50～56Gy/25～30fs/5～6wks,at 2Gy daily,5 days perweek.Results:The 1 ,3 ,5 year survival rates were 53%,40.3%,20% in CFR and 63%,31%,11%in LCHR respectively. There was no significant differences on the survival rates between the two groups ( P >0.05).Conclusion:The results show that the late course hyperfractionation radiotherapy regimen cant improve the long term survival of brain tumors than the convention fractionation radiotherapy.