摘要
目的 :探讨体外试验对EBV抗原表达有抑制作用的中药制剂对EBV VCA IgA抗体阳性自然人群体内抗体滴度的干预作用。方法 :将EBV VCA IgA抗体阳性自然人群随机分为对照组和 2个试验组 ,对照组服安慰剂胶囊 ,试验组分别服用中药制剂抗毒防癌胶囊Ⅰ号和Ⅱ号 ,1个月为 1个疗程 ,停 1周重复第 2疗程 ,共服 3个疗程。治疗前、后分别测定试验对象的血清EBV VCA IgA抗体。 结果 :对照组服药后抗体自然转阴率和滴度下降率为 37 5 0 % ,明显低于试验 1组(5 3 2 3% )和 2组 (5 2 94 % ) (P均 <0 0 1) ;对照组抗体上升率 2 5 0 0 % ,明显高于试验 1组 (6 4 5 % )和 2组 (8 82 % ) (P均 <0 0 1) ,而服药前后抗体不变率 3组差异不明显 (P >0 0 5 )。结论 :中药抗毒防癌胶囊对EBV在体内产生VCA
Objective:To explore the interfering effect of Chinese medicine preparation (producing an inhibitory effect on the antigen expression of EBV in our test in vitro) on the antibody titer in the bodies of natural population with the positive VCA IgA antibody of EBV.Methods:The natural population of positive antibody of EBV was divided at random into one control group and two test groups. The subjects in the control group took placebo capsules, while the ones in the two test groups took the Chinese medicine preparation 'antitoxin and cancer prevention capsule Ⅰ or Ⅱ', respectively. The medicine was given for one month. After a week the second course of treatment was repeated. There were altogether three courses. The antibody titer of VCA IgA of EBV in the serum of the subjects was assayed before and after taking medicine, respectively.Results:The natural transnegative rate and titer descending rate of antibody after taking medicine in the control group was 37 50%, lower significantly than that of test group Ⅰ (53 23%) and test group Ⅱ (52 94)(total P <0 01); the ascending rate of antibody in control group was 25 00%, higher significantly than that of test group Ⅰ(6 45%) and test group Ⅱ(8 82)(total P <0 01); there was no obvious difference among the three groups for the invariant rate of antibody before and after taking medicine ( P >0 05).Conclusion:The preparation 'antitoxin and cancer prevention capsule' may have a fairly interfering effect on the production of VCA IgA antibody of EBV in vivo.
出处
《临床肿瘤学杂志》
CAS
2002年第6期430-432,共3页
Chinese Clinical Oncology
基金
广西壮族自治区科技厅资助课题 ( 97350 2 2 )
