摘要
目的 :研究五丹胃福汤对慢性萎缩性胃炎的作用机制。方法 :用 Wistar大鼠 75只随机分为 5组 ,即正常对照组、造模组、自然恢复组、小剂量治疗组和大剂量治疗组 ,治疗组给予五丹胃福汤进行干预 ,采用单一试剂法检测大鼠胃粘膜及血清超氧化物歧化酶 (SOD)与丙二醛 (MDA)。结果 :五丹胃福汤能够增强萎缩性胃炎大鼠胃粘膜及血清 SOD水平而降低 MDA水平 ,从而减轻自由基对胃粘膜的损害。结论 :五丹胃福汤可有效调节血清及胃粘膜的自由基水平 ,是本方有效治疗萎缩性胃炎的作用机制之一。
Objective: To investigate the mechanism of Wudan Weifu decoction (WWD) in the treatment of chronic atrophic gastritis (CAG). Methods: Seventy-five Wistar rats were divided into 5 groups: normal control group, model group, natural recovery group, low-dose WWD group, high-dose WWD group. The related indexes were tested with single reagent method. Results: WWD could increase the level of SOD in gastric mucosa and plasma, decrease the content of MDA and reduce the injury of free radical to the gastric mucosa. Conclusion: WWD could regulate the levels of free radical in gastric mucosa and plasma of rats with CAG, which might be one of the mechanisms of WWD to treat CAG effectively.
出处
《中国中西医结合消化杂志》
CAS
2002年第6期352-354,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
