高压氧治疗对脑外伤患者血糖的影响

Effect of hyperbaric oxygen on blood sugar level in patients with traumatic brain injury

目的 探讨脑外伤后血糖改变与高压氧疗效之间的关系。方法 选取 70例脑外伤患者为研究对象 ,分为治疗组和对照组 ,以GCS评分判断疗效 ,并测定 2组患者治疗前、后的血糖浓度 ,进行比较判定。结果 治疗组治疗后GCS评分为 (11.9± 1.7)分 ,对照组评分为 (10 .7± 2 .0 )分 ,2组比较差异有非常显著性意义 (P <0 .0 1) ,治疗组疗效明显优于对照组。治疗前治疗组血糖为 (8.5 0± 4.5 5 )mmol/L ,对照组为 (8.76± 2 .78)mmol/L ,2组间差异无显著性意义 (P >0 .0 5 ) ;治疗后治疗组血糖为 (5 .46± 0 .84)mmol/L ,对照组为(6.0 4± 0 .86)mmol/L ,差异有非常显著性意义 (P <0 .0 1) ,治疗组血糖明显低于对照组。结论 脑外伤后血糖显著升高 ;高压氧能提高受损脑组织对葡萄糖的利用 ,使血糖下降 ;高压氧治疗是脑外伤的辅助治疗方法。

Objective To explore the relationship between the effect of hyperbaric oxygen treatment and le vels of blood sugar in patients with traumatic brain injury. Methods Seventy patients with traumatic brain injury were divided into two groups by randomization:the hyperbaric oxygen treatment group and control group. All the patients were evaluated with Glasgow Coma Scale (GCS), while blood sugar in these 70 patients was measured before and after a period (once a day for 10 days) of treatment. Results After 10 days of treatment, GCS of the hyperbaric oxygen treatment group was 11.9±1.7,while GCS of control group was 10.7±2.0,there was significant difference between the two groups ( P <0.01) ; the blood sugar in patients of hyperbaric oxygen treatment group was ( 5.46 ±0.84)mmol/L, while it was (6.04±0.86)mmol/L of control group ,the change was also significant( P <0.01). Conclusion Hyperbaric oxygen treatment is a beneficial approach for patient with traumatic brain injury; determination of blood sugar can be used for estimating the degree of traumatic brain injury and the effect of hyperbaric oxygen treatment.