肝节段动脉栓塞治疗肝癌的疗效观察

Therapeutic efficiency of segmental TACE for hepatocellular carcinoma

目的 :探讨肝节段动脉栓塞化疗治疗肝癌的疗效。方法 :将 1996年 1月～ 1999年 10月 2 32例肝癌患者根据栓塞方式不同分为 2组 ,其中行肝节段动脉栓塞化疗 6 8例 ,行常规栓塞化疗 16 4例 ,对 2组治疗的疗效进行分析。结果 :节段组 1、2、3年生存率分别为 86 8%、6 1 8%和 4 8 5 % ;常规组则相应为 6 7 1%、4 2 1%和 2 6 2 % ,节段组远期生存率明显高于常规组 (P <0 0 1)。肝功能损害程度节段组明显较常规组轻 (P <0 0 1)。结论 :肝节段动脉栓塞化疗对肝功能损害轻 。

Objective To evaluate therapeutic efficacy of segmental transcatheter hepatic arterial chemoembolization (segmental TACE) for hepatocellular carcinoma.Methods Data of 232 cases with unresectable hepatocellular carcinoma from January 1996 to October 1999 were analyzed and were divided into two groups,68 cases were given segmental TACE,while the remaining 164 cases were given TACE.Results The 1 ,2 ,and 3 year overall survival rate were 86 8%,61 8%,48 5% in segmental group respectively,and 67 1%,42 1%,26 2% in conventional group respectively.There were significant difference between the two groups ( P <0 01).Observation of liver function after embolization revealed more serious deterioration in conventional group than that in segmental group( P <0 01).Conclusions Segmental TACE possesses much less damage to liver function and is more superior in long term effectiveness than TACE.