生长因子与椎间盘再生

GROWTH FACTOR AND REGENERATION OF INTERVERTEBRAL DISC

目的 追溯近阶段国内外有关生长因子与椎间盘修复研究的进展。方法 广泛查阅近期有关生长因子与椎间盘修复的文献 ,综述生长因子在椎间盘的表达、生长因子对椎间盘细胞的作用等研究。结果 多种生长因子在椎间盘生长发育和退变过程中表达 ,外源性生长因子能促进培养的椎间盘细胞分化增殖、合成蛋白多糖和胶原 ,运用腺病毒可将生长因子基因转染至椎间盘细胞。 结论 生长因子在椎间盘的生长发育和退变过程中起调节作用 。

Objective To review research progress of the relation between growth factor and repair of intervertebral disc. Methods The recent articles on growth factor and repair of intervertebral disc were extensively reviewed. The expression of growth factor in intervertebral disc and the effect of growth factor on disc cells were investigated. Results Some growth factors play roles in the development and degeneration of intervertebral disc. Exogenous growth factor can increase proliferation of disc cells and production of proteoglycans and collagens. Gene of growth factor can be transferred to intervertebral disc cell by adenovirus. Conclusion Growth factor plays an important role in the regulation of development and degeneration of interertebral disc. The above results show that the feasibility of usage of growth factor in the treatment of disc degenertion and in repair and reconstruction of disc.