摘要
目的 评价皮肤角质层和真皮层对药物经皮吸收的差异。方法 选择氟尿嘧啶 (5 - FU)为模型药物 ,采用Franz扩散池法 ,考察药物经完整皮肤和剥离角质层皮肤的体外透皮能力 (Kp) ,并比较吸收促进剂肉豆蔻酸异丙酯 (IPM)共存时的促透能力大小。结果 5 - FU经剥离角质层皮肤的 Kp是经完整皮肤的 2 .2倍 ,加入IPM后 5 - FU的 Kp分别提高到原来的 1 .6倍 (经完整皮肤 )和 2 .3倍 (经剥离角质层皮肤 )。结论 本实验为皮肤病态条件 ,如皮肤受伤或溃疡等时的药物经皮吸收规律研究提供一种新的方法。
Objective To investigate the influence of skin layers(stratum corneum and viable layer) on the percutaneous absorption of drug with or without isopropyl myristate(IPM). Methods We chosed fluorouracil(5-FU) as a model drug. Patches containing saturated concentration of 5-FU were prepared. The in vitro transdermal permeation experiment via different rat skin layers was carried out. Results The K p of 5-FU via stripped skin was 2.2 times larger than that via intact skin. The permeability was enhanced when coexisting with IPM via intact skin but no significant difference via stripped skin, compared with that via normal skin. Conclusion These data and methods represent a novel approach to evaluate the effects of skin damage and skin disease on drug percutaneous absorption.
出处
《西北药学杂志》
CAS
2002年第6期257-259,共3页
Northwest Pharmaceutical Journal
关键词
氟尿嘧啶
肉豆蔻酸异丙酯
角质层
经皮吸收
抗肿瘤药
fluorouracil
isopropyl myristate
stratum corneum stripped skin
in vitro percutaneous absorption