心肌梗死病人血浆TAT、PAP和FDP水平的变化

Change of Levels of Plasma TAT,PAP and FDP in Patients with Myocardial Infarction.

目的:检测陈旧性心肌梗死(oldmyocardialinfarction,OMI)和急性心肌梗死(acutemyocardialinfarction,AMI)病人血浆凝血酶鄄抗凝血酶复合物(thrombin鄄antithrombincomplex,TAT)、纤溶酶鄄抗纤溶酶复合物(plasmin鄄antiplasmicomplex,PAP),和纤维蛋白原降解产物(fibrinogendegradationproducts,FDP)等分子标志物水平,以探讨心肌梗死(myocardialinfarction,MI)病人体内凝血鄄纤溶系统的变化。方法:选择临床确诊为OMI病人25例、既往无心肌梗死史的AMI病人35例和正常对照28名,采用ELISA法检测血浆TAT、PAP和FDP。结果:OMI组TAT和PAP较正常对照组显著升高,而FDP较正常对照组升高不显著。AMI组TAT、PAP、FDP较正常对照组均显著升高。结论:MI病人凝血、纤溶系统均处于激活状态,TAT、PAP和FDP是监测MI发生的良好指标。

Objective:To study the change of thrombin-antithrombin complex(TAT),pla smin-antiplasmin complex(PAP)and fib-rinogen degradation products(FDP)in patie nts with myocardial.Methods:TAT,PAP and FDP levels were determined in25patients with old myocardial infarction(OMI),35patients with acute myocardial infarction AMI and28age-matched normal controls by ELISA.Results:The plasma TAT and PAP le vels in patients with OMI were increased significantly compared with the control s,and FDP was also increased in varying degree.Plasma TAT,PAP and FDP levels in patients with AMI were significantly increased compared with controls.Conclusion s:The coagulation and fibrinolytic systems are activated in patients with myocar dial infarction.Plasma TAT,PAP and FDP may be the good markers for monitoring t he occurence of myocardial infarction.