餐后高甘油三酯血症对吸烟者血管内皮功能的影响

Influence of Postprandial Hypertriglyceridemia on Endothelial Function in Smokers

目的 :探讨吸烟者餐后甘油三酯代谢与血管内皮功能的关系。方法 :30位吸烟者 (吸烟组 )和 2 0位非吸烟者 (非吸烟组 )禁食 12小时后 ,检测空腹肱动脉血流介导的内皮依赖性血管舒张功能 ,随后接受高脂餐饮食 ,于空腹及餐后 2、4、5、7小时测定血清甘油三酯浓度。结果 :吸烟组血流介导的内皮依赖性血管舒张功能显著受损 (P <0 0 0 1) ,餐后 2 ,4,5 ,7小时血清甘油三酯浓度显著升高 ,与非吸烟组比较 ,有显著性差异 (P <0 0 5 ) ,其甘油三酯曲线下面积显著大于非吸烟组 (P <0 0 5 )。内皮依赖性血管舒张功能与甘油三酯曲线下面积呈显著负相关 (r =-0 35 9,P <0 0 5 )。结论 :吸烟者存在餐后甘油三酯代谢障碍 。

Objective: To assess the association of postprandial triglyceride metabolism with endothelial function in smokers Methods: After fasting for 12 hours, the brachial artery flow mediated vasodilation ( FDM ) was measured by high resolution ultrasound technique in 30 smokers and 20 controls They all accepted a high fat meal Blood samples were tested for serum triglyceride concentrations in fasting state and 2, 4, 5 and 7 hours after the meal Results: The smokers had obviously abnormal FDM compared with the controls 〔(5 5±2 3)% vs (10 1±4 2)%, p <0 001)〕 The postprandial serum triglyceride concentration and the area under triglyceride curve (TG AUC)in 7 hours after high fat meal 〔5 36±2 31 mmol/(L·7h)vs 1 52±1 41 mmol/(L·7h), p <0 05〕 were higher in the smokers The FDM was inversely correlated with the TG AUC( γ =-0 359, p <0 05) Conclusions: The smokers had abnormal triglyceride metabolism which is closely correlated with endothelial dysfunction