多普勒组织成像观察培哚普利对心功能的影响(附80例分析)

Observation of perindopril to cardiac function by Doppler tissue imaging(analysis of 80 cases)

目的 :采用多普勒组织成像 (DTI)方法定量观察培哚普利 (perindopril)对老年人陈旧性心肌梗塞患者心功能的影响。方法 :80例患者随机分成两组 ,试验组为培哚普利 (4mg,qd ,4 0例 )与消心痛 (10mg,tid)联用 ,对照组为消心痛(10mg ,tid)单用组。疗程为 16周。治疗前后患者均行常规二维超声 (2 DE)及DTI检查 ,采用DTI重点测定二尖瓣环(MVR)收缩期运动速度 (MVR Vs)、舒张早期运动速度 (MVR DeV)、舒张晚期运动速度 (MVR DaV) (速度单位为m/s) ,结合M型超声测定左心功能方法测出左室射血分数 (EF)。结果 :试验组治疗前后MVR Vs为 0 .0 76± 0 .0 14和 0 .0 87± 0 .0 13(P <0 .0 1) ;MVR DeV为 0 .0 79± 0 .0 17和 0 .0 88± 0 .0 16 (P <0 .0 5 ) ;MVR DaV为 0 .0 95± 0 .0 14和 0 .10 4± 0 .0 14 (P <0 0 1) ,以及EF为 0 .5 4 2± 0 .0 4 8和 0 .6 81± 0 .0 5 4 (P <0 .0 1)。对照组EF治疗前后为 0 .5 34± 0 .0 4 3和 0 .5 79± 0 .0 4 2 (P <0 0 1) ,而DTI观察指标治疗前后对比无统计学差异。结论 :DTI可定量分析左室壁心肌收缩与舒张功能为临床观察药物疗效、合理选择药物及预后判断提供了定量指标。

Objective:To observe the influence of perindopril to cardiac function of the aging with old cardiac infarction quantitatively by Doppler tissue imaging.Methods:There are 80 cases which are divided into two groups randomly.Combination use of perindopril (4mg qd 40 cases) and vasocardin(10mg tid) in test group.And only vasocardin (10mg tid) in contrast group.The period of treatment is 16 weeks.The patients had the examination of 2-dimensional ultrasound and DTI routinely before and after treatment.The mitral vavular ring systolic velocity(MVR-Vs), early diastolic velocity (MVR-DeV) and end-diastolic velocity (MVR-DaV)were analysed by DTI and the left ventricular ejecton fraction (EF) was measwed by M-mode ultrasound.Results:The values before and after treatment in test group are as follows:MVR-Vs:0.076±0.014 and 0.087±0.013(P<0.01);MVR-DeV:0.079±0.017 and 0.088±0.016(P<0.01); MVR-DaV:0.095±0.014 and 0.104±0.014(P<0.01)EF:0.542±0.048 and 0.681±0.054(P<0.01) and the EF in contrast group before and after treatment is:0.534±0.043 and 0.579±0.042(P<0.01).But there is no statistic difference between before and after treatment by DTI observation.Conclusion:DTI can analyse quantitively the systolic and diastolic cardiac function of left ventricle and provide quantitive standards for clinical drug effects observation,selection of drugs and prognosis of treatment.