猫不同程度脑缺血时的心电图改变

Effect of Various Degree Cerebral Ischemia on the Electrocardiogram in Cats

实验利用猫双侧颈总动脉(bCA)和双侧椎动脉(bVA)中不同数目血管阻断观察了脑缺血对心电图(ECG)的影响。bCA并单侧椎动脉(uVA)或bCA+bVA阻断均引起复杂ECG变化,如Q-T时程从对照值0.21±0.04s分别延长至0.23+0.08s和0.25±0.11 s,心率由179±33次/min分别降至173±27次/min和151±39次/min,与对照值比较P<0.01。结果显示颈动脉窦反射是bCA或bCA±uVA阻断早期出现短暂心律失常的原因;bCA+uVA阻断所致的迟发ECG变化与缺血引起的颅内压(ICP)升高有关;而bCA+bVA阻断引起的窦性心动过缓、室性心律失常等变化是由于脑干缺血所致,与ICP变化无关。结果提示颅内疾病时心动过缓、室性心律失常的出现,可能预示着脑干结构的损害和功能紊乱。

By different numbers of arteries occlusion among bilateral carotid (bCA) and bilateral vertebral arteries (bVA) of cats, effects of cerebral ischemia on the electrocardiogram, (ECG) was studied After bCA plus unilateral vertebral artery (uVA) and bCA+ bVA occlusion the duration of Q-T was prolonged from its control value of 0.21±0.04s to 0.23±0.08s and 0.25±0.1ls, and heart rate was also reduced from its contrl value of 179±33 beat/min to 173±27 beat/min and 151±39 beat/min (P<0.05), respectively. The results showed that aortic sinus reflection was the cause of early arrhythmia after bCA or bCA+uVA occlusion; the late changes of ECG, i.e, Q-T interval prolongation, bradycardia after bCA+uVA occlusion was related to the increase of intracranial pressure (1CP); the changes of ECG, such as bradicardia, multiform ventrical arrhythmias, after bCA+bVA occlusion was result of the brain stem ischemia and was negatively correlation with the changes of ICP. It is suggested that the occurrences of sinus bradicardia, multifocal and multiform ventrical arrhythimia may be a sign of structure damage and function disorder of brain stem in the sufferers from craniacerebral diseases.