摘要
^(99m)Tc标记的拟糖蛋白(^(99m)Tc-NGA)是一种新的肝受体显像配基。用化学方法合成的该配基无菌无热原,无毒副作用,有较好的体内体外稳定性。10只家兔分为对照组(6只)、肝门静脉结扎组(2只)和肝坏死组(2只)。肝静态显像和肝血流动力学检查结果表明:(1)^(99m)Tc-NGA显像可提供良好的肝脏影像,(2)肝血流动力学检查是诊断肝疾病的新手段。
Technetium-99m galactosyl-neoglycoalbumin (99mTc-NGA) is a new hepatocellular receptor imaging ligand Its preparation and preclinical research are reported in this paper. The ligand was synthesized by the chemical coupling and the product was nontoxic and apyrogenic with good stability both in vivo and in vitro. The static images and kinetic data obtained from the liver portal vein ligation group (n = 2), the hepatic necrosis group (n=2) and the control group (n=6) indicate: (1) Tc-NGA imaging can provide excellent hepatic images, and (2) hepatic kinetic data appear to provide a new means for diagnosis of liver diseases.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1992年第1期66-69,共4页
Academic Journal of Second Military Medical University
关键词
显像
受体
配位体
肝细胞癌
肝疾病
radionuclide imaging receptors
ligands
hepatoma