摘要
本文总结了使用环孢素(CyA)行抗排异治疗的366例肾移植病人出现肝功能异常的临床资料。其肝毒性的发生率为25.68％(94/366);死亡13例;肝毒性的发生时间为7～84d,持续时间5～96d。结果表明:HBsAg阳性,原有肝功能异常及老年病人不适宜使用CyA。
Hepatotoxicity of cyclosporine A was investigated in 366 patients who received renal allografts, of whom 94 (25.68%) presented hepatotoxicity and 13 (3.55%) died. Hepatotoxicity appeared between 7 and 84 d, and lasted for 5 to 96 d. Our study suggested that cyclosporine A is not suitable for older patients with positive HBsAg and liver disfunction.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1992年第5期443-446,共4页
Academic Journal of Second Military Medical University
关键词
环孢素A
肝毒
发病率
肾
移植术
cyclosporine A
hepatotoxicity
renal allografts
incidence
