复方甲苯咪唑乳膏涂肤剂对小鼠旋毛虫病的疗效

Efficacy of Mebendazole Composite Cream in Treatment of Trichiniasis in Mice by Skin Administration

小鼠感染旋毛虫后,于成虫期用复方甲苯咪唑乳膏涂肤剂50mg/kg×1d,减虫率为97.3％;幼虫移行期和成囊期用复方甲苯咪唑乳膏涂肤剂25mg/kg×7d,减虫率达100％和99.7％。结果表明,复方甲苯咪唑乳膏对小鼠旋毛虫成虫,幼虫移行期和肌肉内成囊期都有较好的治疗效果。

Male mice weighting 25-32g were infected with larvae of Trichinella spiralis. Skin administrations of mebendazole composite cream were carried out on the mice in 3 different experiment groups. It was found that there were the reduction rate of worms at 97.3%, 100% and 99. 7% in the adult worm group (50 mg/kg x 1 d), in the invasive larvae group (25 mg/kg x 7 d) and in the encysted larvae group (25 mg/kg x 7 d), respectively. These results indicate that mebendazole composite cream is very effective against both intestinal and muscular phases of T. spiralis.