安定对兔体内苯妥因钠药代动力学的影响

The effects of diazepam on phenytoin pharmacokinetics in rabbits

本文应用荧光偏振免疫分析法测定了家兔肌注安定前或1周后静注笨妥因钠的血药浓度,计算其药代动力学参数。结果表明,安定能明显影响兔体内苯妥因钠的药代功力学。12h时两组血药浓度相差非常显著,给安定后苯妥因钠的t_(1/2)明显延长,药代动力学模型由原来一室开放模型变为二室开放模型,而AUC和清除率无明显改变。

The serum level of intravenously dripped phenytoin was deter- mined in rabbits before and in different time intervals of a week after intramuscular injection of diazepam with fluorescence polarization immunoassay and the parameters were calculated on a microcomputer.It was found that in the 12th hour after diazepam injection,the serum level of phenytoin was significantly different from that of the control,and t1/2 of phenytoin was significantly prolonged;the model of pharmacokinetics of phenytoin was changed from one compartment open model to two compartment open model.Yet the AUC and Cl of phenytoin were not markedly altered.