大鼠急性胆道感染时多脏器损伤的病理学观察

Pathological changes of multiple organ damages due to acute obstructive cholangitis in rats

本实验通过复制大鼠急性梗阻性胆管炎动物模型,动态观察大鼠主要内脏器官组织学和超微结构变化。结果发现,急性胆道感染大鼠各内脏器官可出现广泛,严重的病理学变化。其基本病变为血液循环障碍,实质细胞变性、坏死及炎症反应。其中,肝脏损伤最显著。

The pathological changes of the damages on many vital organs during acute obstructive cholangitis were observed in 45 rats under optical and electron microscopy.The morphological changes of the vital organs were characterized by disturbance of blood circulation,degeneration and/or necrosis of the tissues and cells,and inflammatory reactions.The hepatic damage appeared earlier and more severe thna the other organs during acute obstructive cholangitis.