前列环素、血栓素在缺血性肾损害中的作用

Study on the significance of prostacyclin and thromboxane in the pathogenesis of ischemic renal injury in rabbits

采用兔肾缺血模型,用放免方法测定血浆及组织内6-keto-PGF_(1α)和TXB_2的变化。结果提示肾缺血再灌流早期内、外髓质6-keto-PGF_(1α)及全肾组织TXB_2显著增加,6-keto-PGF_(1α)/TXB_2比值则显著下降。6-keto-PGF_(1α),TXB_2的异常代谢可能是缺血再灌流早期肾血流量减少和血流再分布的重要原因。

In order to investigate the significance of prostacyclin and throm-boxere A2 in the pathegertsis of ischemic renal injury,the level of 6-keto-PGF1α and TXB2 in the plasma and the dissected slices of the kidneys of the rabbits with iscbemic renal injury was determined with RIA,It was found that 6-keto-PGF1α increased significantly in the outer and inner medullae,TXB2 increased significantly in all the renal slices,and the 6-keto-PGF1α/TXB2 ratio decreased significantly in the outer cortex 3 hours after reperfusion,The findings suggest that the imbalance between the synthesis of prostacyclin and thromboxane A2 might be resporsible for the decline and redistribution of renal blood flow in the early stage of acute ischemic renal failure.