MC_5免疫组化在结直肠腺癌的定位与预后关系的探讨

The significance of immunohistochemical localization of MC5 in the diagnosis and prognosis of colorectal adenocarcinoma

对215例结直肠腺癌行MC_5单克隆抗体免疫组化定位类型的研究,发现极向型主要见于高分化癌;弥漫型主要见于低分化癌。根据133例回访,极向型的5年生存率为74.4％,弥漫型为36.2％。两型比较相差非常显著(P<0.01)。此外,免疫组化类型还与组织学类型、分化程度以及Duke's氏分期相关。作者认为MC_5免疫组化类型可能为一种新的判测预后的重要因素,如结合传统的判测因素能更准确监测结直肠腺癌的预后。

The pattern of immunohistochemical localization of monoclonal antibody MC5 was observed in 215 cases of colarectal adenocarcinoma.It was found that the polarized pattern was predominant in the well-differentiated adenocarcinomas while the deffuse pattern in poorly-differentiated ade-nocarcinomas.Followup study of 133 cases revealed that 5-year sunvival rate was 74.4% in cases with polarized pattern and 36.2% in those with diffuse pattern,a very significant difference between the 2 (P<0.01).In addition,there was a reciprocal correlation between the immunohistochemical pattern and the histological classification,the degree of differentiation,the Dukes' stage of colorectal adenocarcinoma.It is believed that the pattern of immunohistochemical localization of MC5 is a new important factor to assess the prognosis of colorectal adenocarcinoma,and if it is used in combination with the other predictive factors,more accurate prognosis of colorectal adenocarcinoma is possible.