慢性肺心病患者血小板数种功能的研究

A study on platelet function in patients with cor pulmonale

本文测定了25例缓解期肺心病患者β血栓球蛋白(β-TG)、血小板第Ⅳ因子(PF_4)血浆浓度和血小板聚集率(PAR)。结果肺心病患者β-TG、PF_4、β-TG/PF_4及PAR均显著大于正常对照组,β-TG血浆浓度与动脉血氧分压呈负相关(r=-0.46 P<0.01),β-TG与PF_4呈正相关(r=0.57,P<0.01)。提示肺心病患者存在血小板体内激活,讨论了肺心病患者血小板体内激活的原因和后果。

The plasma levels of β-thromboglobulin (β-TG) and platelet factor 4 (PF4) and the platelet aggregation rate (PAR) were determined in the remission stage of 25 cases of chronic cor pulmonale.β-TG,β-TG/PF4,PF4,and PAR all were significantly higher in the patients with cor pul-monale than in the normal subjects (P<0.01-0.05 respectively).Plasma β-TG was negatively correlated with PaO2(r=-0.46,P<0.01).The findngs suggest that in the patients with chronic cor pulminale,the functions of platelets are activated.The causes and the significance of platelet activation were discussed.