肝炎肝硬化患者淋巴细胞亚群与发生感染的关系初探

Relationship between lymphocyte subsets and bacterial infection in patients with liver cirrhosis

目的探讨肝炎肝硬化患者发生细菌感染与外周血淋巴细胞亚群各指标的关系。方法选择肝炎肝硬化患者77例,其中发生感染者25例,未发生感染者52例,对2组患者的外周血白细胞数、淋巴细胞亚群绝对数(包括CD_4^+、CD_8^+细胞、NK细胞、B细胞)、CD_4^+/CD_8^+比值进行比较。结果发生感染组CD_4^+ T细胞绝对数(462.38±286.52)较未发生感染组(711.34±501.26)低,P<0.05;感染组CD_8^+ T细胞绝对数(301.46±177.71)也较未发生感染组(482.02±370.48)低,P<0.05。结论肝炎肝硬化患者CD_4^+ T细胞数和CD_8^+ T细胞数低者更容易发生细菌性感染。

Objective To investigate the relationship between lymphocyte subsets and bacterial infection in pa- tients with liver cirrhosis. Methods The clinical data of 2S liver cirrhosis patients with bacterial infection were compared with those of 52 patients without the infection. Routine blood tests were conducted and lymphocyte subsets including T cells, B cells, NK cells before the infection detected in all the 77 patients. Meanwhile, CD_4^+ and CD_4^+ subset T cells were classified. Results The absolute counts of CD_4^+ and CD_8^+ T cells were significantly lower in infected patients than those in uninfected ones (P<0. 05). Conclusions The liver cirrhosis patients with a low absolute counts of CD_4^+ and CD_8^+ T cells are more susceptible to bacterial infection.