补肾清热毒方联合西药治疗狼疮性肾炎的疗效观察

Observation on Therapeutic Effect of Bushen Qingredu Recipe Combined with Western Medicine in Treating Lupus Nephritis

目的:探讨补肾清热毒方联合西药治疗狼疮性肾炎的疗效。方法:对照组采用常规西药治疗,治疗组(80例)患者在采用西药有效控制症状的基础上,加用中药补肾清热毒方治疗,观察两组治疗前后症状、体征及实验室相关指标。结果:总有效率治疗组为91.25％,对照组为70.77％,两组比较差异有显著性(x2=lO.962,P<O.05)。治疗组自身抗体、补体、血脂、24h尿蛋白、肾功能和肾脏病理变化均有显著改善(P<0.05或P<0.01)。结论:补肾清热毒方联合西药治疗狼疮性肾炎疗效明显优于单纯西药治疗。

To explore the curative effect of Bushen Qingredu recipe (BSQRD) combined with western medicine in treating active lupus nephritis (LN). Methods: Eighty patients in the treated group were treated with BSQRD for 3 months on the basis of controlling auto-immune response effectively by conventional western medicine. The symptoms, signs and related laboratory indexes before and after treatment were observed and compared with those in 65 patients treated by western medicine alone as control. Results: The total effective rate in the treated group was 91.25% and that in the control group was 70.77%, comparison between the two showed significant difference (x2 = 10.962, P<0.05). The related laboratory indexes, including auto-antibody, complement, blood lipids, 24 hrs urinary albumin excretion, renal function as well as the pathological changes of kidney were all significantly improved after treatment in the treated group (P<0.05 or P<0.01). Conclusion: The therapeutic effect of BSQRD recipe combined with western medicine is better than that of western medicine alone in treating LN.