黄芩甙对糖尿病患者周围神经传导速度和尿微量白蛋白排泄的影响

Effect of Baicalin on Nerve Conduction Velocity and Urinary Microalbumin Excretion in Patients with Diabetes Mellitus

目的:为观察中药黄芩甙对糖尿病患者周围神经传导速度和尿微量白蛋白排泄的影响及临床意义。方法:将病程5年以上的74例糖尿病患者,随机分为黄芩甙治疗组和对照组,对照组常规治疗,黄芩甙治疗组在常规口服降糖药或胰岛素治疗的基础上,每日加服黄芩甙胶囊3g,连续观察治疗6个月。结果:黄芩甙治疗组,治疗后醛糖还原酶(AR)活性显著降低,尿微量白蛋白排泄率较对照组明显减少,神经传导速度趋于稳定和部分改善,而对照组未见明显改善。结论:黄芩甙具有明显抑制AR活性作用,并可有效的改善糖尿病患者周围神经传导速度,减少尿蛋白,对糖尿病肾病及神经病变具有改善和延缓作用。

To observe the effect of baicalin on periperal nerve conductive velocity (NCV) and urinary mi-croalbumin excretion (UMAE) in patients with diabetes mellitus and to explore its significance. Methods: Seventy-four patients of diabetes mellitus with duration of disease more than 5 years were randomly divided into 2 groups. Conventional treatment was given to them all, and to the patients in the treated group, additional 3 g baicalin capsule was given once a day for 6 continuous months. Results: In the treated group, aldose reductase activity in red blood cell was significantly lowered and UMAE reduced markedly after treatment. Meantimes, the NCV in them was tended to stabilize and partial improved, while that in the control group worsened further. Conclusion: Baicalin has effect in inhibiting activity of aldose reductase, it could improve the NCV and decrease the UMAE in diabetes patients, so as to improve or delay the occurrence of complicated nephropathy and neuropathy .