摘要
目的 : 研究膳食黑米皮对高脂诱导的家兔动脉粥样硬化形成的抑制作用。方法 : 雄性新西兰大耳白家兔 3 2只 ,体重 2 .1 6± 0 .1 2 kg。按体重随机分为四组 ,分别饲以正常基础饲料、高脂饲料 (含 96 %基础饲料、0 .5 %胆固醇、3 .5 %猪油 )、白米皮饲料 (含 91 %基础饲料、0 .5 %胆固醇、3 .5 %猪油、5 %白米皮 )、黑米皮饲料 (含 91 %基础饲料、0 .5 %胆固醇、3 .5 %猪油、5 %黑米皮 ) ,另外 ,用酪蛋白及蔗糖将各组饲料的蛋白质含量和总能量分别调至平衡。喂饲 6 0 d后 ,处死家兔 ,用图像分析法测定各组家兔主动脉脂质斑块面积。结果 : 黑米皮组的实验家兔主动脉壁斑块面积较高脂组低 6 6 % (P<0 .0 0 1 ) ,较白米皮组低 75 % (P<0 .0 0 1 ) ;白米皮组和高脂组之间主动脉壁斑块面积无显著性差异。结论 : 膳食黑米皮可以抑制高脂诱导的家兔动脉粥样硬化形成 。
Objective: The influence of dietary black rice outer layer fraction consumption on atherosclerotic plaque formation induced by high cholesterol diet was investigated in rabbits. Methods: Male rabbits (n=32) were divided into four groups. They were fed a normal laboratory ribbit diet (normal group, n=8); a normal diet with high cholesterol 0.5 g/100 g, lard 3.5 g/100 g (HC group, n=8); a HC diet with 5 g/100 g white rice outer layer fraction (WRF group, n=8) or a HC diet with 5 g/100 g black rice outer layer fraction (BRF group, n=8) for 60 days. Aorta was removed for assessment of atherosclerotic plaque by image analysis at the end of the protocol. Results: The area of atherosclerotic plaque in rabbits fed the BRF diet was 66% lower than in those fed the HC diet and 75% lower than in those fed the WRF diet. There was no significant difference in plaque area of rabbits fed HC and WRF diets. Conclusion: Supplementation of dietary black rice outer layer fraction can decrease the atherosclerotic plaque formation induced by hypercholesterolemia in rabbits.
出处
《营养学报》
CAS
CSCD
北大核心
2002年第4期372-376,共5页
Acta Nutrimenta Sinica
基金
国家自然科学基金资助项目 ( 30 0 2 5 0 37
39870 5 37)
关键词
大米
黑米皮
白米皮
动脉粥样硬化
家兔
rice
black rice outer layer fraction
white rice outer layer fraction
atherosclerosis
rabbit