结直肠癌绒毛膜促性腺激素的免疫组化研究

An immunohistochemical study of human chorionic gonadotropin in 40 cases of colorectal carcinoma

用PAP法研究40例结直肠癌绒毛膜促性腺激素β亚单位的定位情况,其中9例阳性。分别为Dukes’A期2例,Dukes’B期4例,Dukes’C期3例;占A、B、C各病例总数的7.7％、44.4％和60.0％。阳性细胞多位于浸润区呈小簇状或散在分布,提示结直肠癌产生HCG可能与更富于侵袭性的生物学行为有关,HCG免疫组化检查可能为监测结直肠癌恶性生物学行为的指标之一。

The localization of the β-subunits of human chorionic gonadotropin(HCG)in 40 cases of colorectal carcinoma was investigated with PAP method.It was found that 9 cases out of the 40 were positive,in which 2 were Dukes' stage A,4 Dukes' stage B and 3 Dukes' stage C,accounting for 7.7%,44.4% and 60.0% of the total number of the corresponding Dukes' staging of this series.The positive cells were mainly situated in the infiltrating portions and distributed in clusters or diffusely.It is suggested that immunohistochemical study of HCG in colorectal carcinoma can be one of the indices in the monitoring of the malignant biological behaviors of colorectal carcinomas.