摘要
目的 : 研究菜籽蛋白经酶水解产生菜籽肽 (RSP) ,抑制小鼠体内 S180 肉瘤的生长和对小鼠免疫功能的影响。方法 : 采用小鼠 S180 实体瘤模型 ,观察小鼠的肿瘤重量、淋巴细胞转化能力、脾细胞抗体形成及血清溶血素含量的变化。结果 : 与环磷酰胺比 ,菜籽肽对 S180 肉瘤生长有抑制作用 ,同时明显增强小鼠免疫能力。结论 : 菜籽肽具有增强免疫能力和抑制肿瘤生长的潜力 。
Objective: To study the inhibition effect on Sarcoma 180 (S 180 ) and immune enhancing effect of rapeseed peptides (RSP) from enzymolysis of rapeseed protein. Methods: S 180 -bearing mice were used as animal model. The changes of tumor weight, lymphocyte proliferation, antibody in splenic cells and hemolysin were investigated. Results: Compared with cyclophosphamide (Cy), RSP inhibited S 180 growth markedly and enhanced immune function .Conclusion: RSP has potential in enhancing immune function and inhibiting tumor growth, but it deserves for further study.
出处
《营养学报》
CAS
CSCD
北大核心
2002年第4期405-407,共3页
Acta Nutrimenta Sinica
基金
湖北省科技攻关重点计划项目 ( 2 0 0 1G170 0 5 )
关键词
菜籽肽
S180肉瘤
肿瘤抑制
免疫功能
rapeseed peptides
Sarcoma 180
tumor inhibition
immunological function
