东菱克栓酶治疗急性脑梗死凝血与纤溶系统的研究

The Study of Batroxobin in the Treatment of Coagulation and Fibrinolytic System in Acute Cerebral Infarction

目的探讨东菱克栓酶治疗急性脑梗死对凝血与纤溶系统的影响及意义。方法检测3C例急性脑梗死患者治疗前后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fg)、D-二聚体水平。正常对照组20人。结果脑梗死患者组治疗前跟正常对照组相比各项指标均有显著性差异(P<0.05),脑梗死患者组PT、APTT较短,纤维蛋白原含量较高,D-二聚体稍有增加;治疗后与治疗前相比PT、APTT明显延长,纤维蛋白原大幅降低,D-二聚体含量大幅增加(P<0.01)。结论 脑梗死患者体内呈高凝状态,导致血栓形成。用东菱克栓酶治疗后,使高凝变为低凝,激活纤溶系统,从而栓予溶解及血管再通。凝血和纤溶系统在整个疾病过程中起到了中间环节的作用,观察凝血和纤溶系统的变化对诊断及治疗脑梗死具有重要的临床意义。

Objective To explore the effects of Batroxobin on coagulation and fibrinolytic system in patients with acute cerebral infarction.Methods The levels of prothombin time(PT), activated partial throm-boplasmin time(APTT), fibrinogen(Fg), D - Dimer were measured in 30 patients before and after treatment with Batroxobin. There are 20 cases in the control group.Results Compared with the contrl group, before treatment PT and APTT levels were significantly decreased,fibrinogen (Fg) and D - Dimer levels were increased (all P < 0.05). After treatment PT and APTT were prolonged. Fg levels greatly decreased, D - Dimer levels were significantly increased(all P < 0.01) . Conclusions The activity of coagulation system of patients with acute cerebral infarction is higher than that in normal. It is the important reason of thrombus formation. Batroxobin will reduce the coagulation activity and increase the fibrinolytic activity accelerate thrombus dissolving. Coagulation and fibrinolytic system is intermediate link of the whole process. To observe changes of coagulation and fibrinolytic system will have great significance in diagnosis and trreatment.