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血管形成素-1与微血管通透性 被引量：2

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摘要 血管形成素(Angiopoietin,Ang)为血管内皮细胞(endothelial cells,ECs)特异性受体酪氨酸激酶Tie-2的配体,是一类新发现的血管生成因子,它与血管内皮生长因子(vascularendothelial growth factor,VEGF)共同作用,协同调节血管的发生、形成过程[1]。Ang-1是Tie-2的主要生理配体,其功能涉及:募集与支持血管内皮周围细胞、诱导毛细血管发芽、ECs趋化反应和ECs网络形成[2]、与抗ECs凋亡有关[3,4]。Ang-1或Tie-2基因敲除的小鼠心脏。
作者 郑阳春 周总光 唐昱英
机构地区 四川大学华西医院肝胆胰外科/微循环研究室 四川大学华西医院麻醉科
出处 《中国微循环》 2002年第6期371-373,共3页 Journal of Chinese Microcirculation
基金 国家杰出青年基金项目资助(39925032)
关键词 Ang受体 血管形成素-1 微血管通透性
分类号 R331.35 [医药卫生—人体生理学]
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参考文献17

  • 1Davis S, Aldrich TH, Jones PF, et al. Isolation of angiopoietin-1, a ligand for the Tie2 receptor, by secretion-trap expression cloning[J]. Cell. 1996,87(7): 1161～1169
  • 2Papapetropoulos A, Garcia-Cardena G, Dengler TJ, et al. Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization,cell survival, and interaction with other angiogenic growth factors [J] . Lab Invest. 1999,79(2) :213～223
  • 3Kwak HJ, So JN, Lee S J, et al. Angiopoietin-1 is an apoptosis survival factor for endothelial cells [J]. FEBS Lett. 1999,448(2～3):249～253
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  • 5Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis[J] . Science. 1997, 277(5322) :55～60
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  • 8Grosios K. Leek JP, Markham AF, et al. Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3 ～＞ q23 and, 8p23. l, respeetively, by in situ hybridization and radiation hybrid mapping[J]. Cytogenet Cell Genet. 1999.84( 1～2): 118～120
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同被引文献32

  • 1王述昀,赵克森.血管通透性的调节和游离微血管技术在其研究中的应用[J].中国病理生理杂志,2005,21(1):203-208. 被引量：8
  • 2袁斯明,邢新,欧阳天祥.婴幼儿血管瘤的起源及其病理演变机制[J].中华整形外科杂志,2005,21(1):66-68. 被引量：8
  • 3Kadl A,Leitinger N.The role of endothelial cells in the resolution of acute inflammation[J].Antioxid Redox Signal,2005,7(11-12):1744-1754.
  • 4McVerry BJ,Garcia JG.Endothelial cell barrier regulation by sphingosine 1-phosphate[J].J Cell Biochem,2004,92(6):1075-1085.
  • 5Kendall S,Michel CC.The measurement of permeability in single rat venules using the red cell microperfusion technique[J].Exp Physiol,1995,80(3):359-372.
  • 6Lum H,Roebuck KA.Oxidant stress and endothelial cell dysfunction[J].Am J Physiol Cell Physiol,2001,280(4):C719-C741.
  • 7Yung LM,Leung FP,Yao X,et al.Reactive oxygen species in vascular wall[J].Cardiovasc Hematol Disord Drug Targets,2006,6(1):1-19.
  • 8Michel CC,Curry FE.Microvascular permeability[J].Physiol Rev,1999,79(3):703-761.
  • 9Bazzoni G,Dejana E.Endothelial cell-to-cell junctions:molecular organization and role in vascular homeostasis[J].Physiol Rev,2004,84(3):869-901.
  • 10Navarro P,Ruco L,Dejana E.Differential localization of VE-and N-cadherins in human endothelial cells:VE-cadherin competes with N-cadherin for junctional localization[J].J Cell Biol,1998,140(6):1475-1484.

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中国微循环
2002年 第6期

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