粉防己碱对吸入伤家兔肺表面活性物质活性的影响及意义

Effects of tetrandrine on pulmonary surfactant activity after inhalation injury in rabbits

本文探讨了肺泡表面活性物质变化与兔吸入伤肺水肿的关系;同时,还探讨了钙拮抗剂粉防己碱(Tet)对肺的保护作用与减少肺表面活性物质破坏的关系。结果发现:致伤后肺泡表面活性物质下降同时,PaO_2下降,PaCO_2升高,肺血管外水量也显著增加。病理检查示肺部炎症水肿性改变。Tet治疗组,肺表面活性物质破坏减少,血气改善,肺部炎症及水肿减轻。提示Tet减轻肺损伤的作用,至少部分是通过减少肺表面活性物质破坏。并提出Tet可能是通过抑制磷脂酶A_2活性,减少肺表面活性物质分解而发挥作用的假设。

The rabbit model of smoke inhalation injury was employed to study the relationship between the decreased activity of pulmonary surfactant and the development of pulmonary edema in inhalation injury and the therapeutic effects of tetrandrine on pulmonary damages.Aftersmoke inhalation injury,the decreased activity of pulmonary surfactant,hypoxemia.hypercapnia,pulmonary inflammation,and pulmonary edema were seen.Tetrandrine could alleviate the pathological manifestations of the lungs,improve hypoxemia and hypercapnia.and protect the surfactant from being destroyed.These findings imply that tetrandrine plays a protective role on the lungs partly due to its protection of pulmonary surfactant from being destroyed.It was suggested that the inhibition of phospholipase Az by tetrandrine might result in the protection of pulmonary surfactant.