电针对大鼠急性脑梗塞血浆中cAMP、cGMP含量的影响

The Effect of Electroacupuncture on Plasma cAMP and cGMP Contents in Rat's Acute Cerebral Infarction

目的 探讨针刺治疗急性脑梗塞的作用机理。方法 采用线栓法复制急性脑梗塞模型 ,采用放免技术 ,检测电针前后血浆中的 c AMP、c GMP含量的影响。结果 电针后可使其血浆中过度降低的 c AMP含量明显升高而趋于常值 ,使升高的c GMP含量有下降的趋势 ,使 c AMP/ c GMP值升高而趋于正常。结论 针刺可能是通过调节 c AMP、c GMP含量及二者的值 ,改善梗塞区脑组织供血 。

Purpose To investigate the mechanism of acupuncture treatment of acute cerebral infarction. Method A model of acute cerebral infarction was made by inserting thread Radiommunoassay was used to measure plasma cAMP and cGMP contents before and after electroacupuncture.Results Electroacupuncture made extremely low plasma cAMP content rise markedly and tend to be normal, high plasma cGMP content tend to drop and cAMP/cGMP ratio rise and tend to be normal. Conclusion Acupuncture may produce a therapeutic effect by regulating cAMP and cGMP contents and a ratio between the two and improving the blood supply to the brain tissue in the infarct area.