产前多疗程地塞米松与早产儿结局的初步临床研究

The effects of prenatal multi-course Dexamethasone on the outcome of premature infants

目的 探讨产前重复剂量地塞米松对早产儿的影响。方法 回顾分析 196例产前不同疗程地塞米松对早产儿影响的临床资料。结果 多疗程组早产儿围生期感染、病死率明显高于单一疗程组 ,两组早产儿头围、出生体重、新生儿呼吸窘迫综合征 (NRDS)、新生儿缺氧缺血性脑病 (HIE)、新生儿脑室内出血 (IVH)、新生儿坏死性小肠结肠炎 (NEC) ,差异无显著性 (P >0 .0 5 )。结论 产前多疗程地塞米松可增加早产儿围生期感染及病死率 ,而对早产儿头围、出生体重及NRDS、HIE、IVH、NEC的发生影响不大。但这一结论仅限于对早产儿的短期影响 ,尚需临床长期动态观察 ,故对此治疗方法应持谨慎态度。

Objective To assess the effects of prenatal repeated dose of dexamethasone on the outcomes of premature infants. Methods Clinical records from 196 cases with prenatal different course treatment of Dexamethasone (the multi-course group) were retrospectively analyzed. Results The perinatal infection rate and the mortality in the multi-course group were higher than those in the single-course group, but the differences of head circumference, birth weight, newborn respiratory distress syndrome (NRDS), newborn hypoxic ischemic encephalopathy (HIE), intraventricular hemorrhage of newborn (IVH) and necrotizing enterocolitis of newborn (NEC) between these two groups were not significant, P>0.05. Conclusions The prenatal multi-course treatment of Dexamethasone would highlight the perinatal infection and the mortality in premature infants. But the drug was ineffective on the infants' head circumference, birth weight, and NRDS, HIE, IVH and NEC. This conclusion was limited on the short-term effects on premature infants, long-term clinical observation was necessary to be done. And the treatment therapy should also be caution to be carried out.