19例心房粘液瘤的免疫组化研究

An immunohistochemical study on 19 cases of cardiac myxoma

为阐明CMS的组织起源,本文对19例CMS作了免疫组化研究。结果表明,全部病例的肿瘤血管及肿瘤间质细胞对Vimentin显阳性反应;成熟血管内皮细胞对UEA显阳性反应;部分粘液瘤的间质细胞与血管平滑肌细胞对Desmin和Myosin显阳性或弱阳性反应;少数病例的部分瘤细胞对S-100蛋白显弱阳性或阳性反应;全部CMS的上皮性标记物AE_1和AE_3均为阴性。研究表明,CMS具有多种间充质细胞成分,它们均可能同源于多潜能原始间叶组织。瘤细胞对免疫组化反应的差异,反映了肿瘤组织的分化和成熟程度可能有差异。文中对CMS的病理组织学和组织化学也作了观察和分析。

Nineteen cases of cardiac myxoma were studied immunohistochemically in order to elucidate the histogenesis of the tumor.It was found that the blood vessels and the stromal cells of all the tumors were positive to vimentin.the matured endothelial cells of blood vessels were positive to UEA.the stromal cells and the smooth muscle cells of blood vessels of a part of the tumors were positive or weak-positive to desmin or myosin.a part of the tumor cells of several myxomas were weak-positive or positive to S-100 protein,and the epithelial markers of AE1 and AE3 were negative in all the cardiac myxomas.Our study revealed that there were various kinds of mesenchymal cells in cardiac myxomas and they might originate from multipotential primeval mesenchymal tissues.The difference of im-munohistochemical reactions of tumor cells reflects the difference of the maturity and differentiation of the tumor tissues.The histopathology and histochemistry of cardiac myxoma were also observed and analyzed.