胃大部切除术对胰岛素、胃泌素释放的影响

The effects of different types of subtotal gastrectomy on the secretion of insulin and gastrin

本文对B Ⅰ式(n=10)、B Ⅱ式(n=15)及保留幽门胃窦浆肌瓣式胃切除术(PAFPG,n=15)术后1～24月的病人以及健康对照者(n=8)的血浆胰岛素及血清胃泌素进行动态测定,发现服高渗葡萄糖液后,B Ⅰ组、B Ⅱ组血浆胰岛素浓度均显著高于PAFPG组,而PAFPG组与对照组无显著性差异。服高渗葡萄糖液后血清胃泌素的变化是B Ⅰ组、PAFPG组及对照组较B Ⅱ组显著。造成术后激素水平的差异性可能与胃肠吻合方式有关。

Blood samples were collected from 10 cases with Billroth Ⅰ gastrectomy(BI),15 cases with Billroth Ⅱ gstrectomy(BⅡ),and 15 cases with pyloroantral flap preserving gastrectomy(PAFPG)were examined to evaluate the changes of plasma insulin and serum gastrin.The blood samples of 8 normal subjects were examined likewise to serve as control.The blood samples were collected in intervals before and after the subject had taken hypertonic glucose solution.It was found that plasma insulin was significantly higher in BⅠ and BⅡ group than in PAFPG group,but it showed no significant difference between the PAFPG group and the control.Serum gastrin was signficantly higher in PAFPG group,BⅠ group,and the control than in BⅡ group.These findings suggest that the changes of insulin and gastrin secretion vary with the type of subtotal gastrectomy.