国产米利酮治疗严重心力衰竭患者的血流动力学变化及临床观察

Hemodynamic and clinical observations on patients with severe congestive heart failure treated with Chinese-made milrinone

应用国产米利酮对15例严重心力衰竭患者治疗的急性血流动力学效应及临床观察表明,用药后心指数增加62.1％,肺毛细血管嵌压及体、肺循环阻力分别下降48.9％、43.0％、49.5％(P均<0.01)。心率及反映心肌氧耗量的参数无明显变化。临床总有效率为86.7％,无血小板减少及致心律失常作用,运动耐受时间延长。用药后血浆cAMP明显增加。结果表明国产米利酮是治疗严重心衰的理想药物。

Hemodynamic and clinical observations were performed on 15 patients with severe congestive heart failure treated with Chinese-made milrinone.It was found that after treatment with milrinone,cardiac index was significantly increased,pulmonary capillary wedge pressure,systemic vascular resistance,and pulmonary vascular resistance were significantly decreased,and heart rate and myocardialoxygen consumption remained unchanged.Tolerance exercise test was prolonged and plasma cyclic AMP was increased.No thrombocytopenia or pro-arrhythmic effect was observed.The total clinical efficacy of the drug was 86.7%.These facts suggest that the Chinese-made milrinone is the durg of choice for the management of patients with congestive heart failure.