炎性反应与肠源性感染的关联性

The relationship between incontrollable inflammation and gutoriginated infection in mice

失控的炎性反应和补体活化参与多脏器功能衰竭的发病过程。而因肠粘膜屏障功能衰竭造成的大量肠道细菌和内毒素侵入体内协同作用形成的肠源性感染在多脏器功能衰竭发病中所起的作用又日益受到关注。本研究给动物注射一种补体活化和炎性反应的活化因子——酵母多糖,观察炎症和感染两者间的内在关联性。结果发现,亚致死量的酵母多糖(0.1mg/g)可损伤肠粘膜屏障而导致肠道细菌侵入体内。而蛋白质营养不良却显著强化了酵母多糖的上述病理效应,使动物形成致死性的全身性肠源性感染,感染的严重性和动物的病死率随营养不良的程度进行性增高。结果表明,在体内失控的炎性反应和肠源性感染有协同致病效应。

It is known that incontrollahle inflammation and activated complement are implicated in the pathogehesis of multiple organ failure.Recently,the role of gut originated infection resulting from the combined action of bacterial translocation due to the functional failure of gut mu-cosal barrier and endotoxin in the pathogenesis of multiple organ failure receives increasing attention.In order to clarify the relationship between incontrollable inflammation and gut-originated infection,zymosan,an activation agent for complement and inflammatory response,was injected to normally nourished mice (NNM) and protein deficient malnourished mice (MNM).It was found that a sublethal dosage of zymosan (0.1mg/kg) could damage the gut mucosal barrier to result in bacterial invasion,which was limited to the mesenteric lymph nodes in MNM.Protein-deficient malnutrition enhanced the pathological effect of zymosan to result in a bacterial spreading to the liver,the spleen and blood stream and a potentially lethal gut originated infection.The severity of infection and the mortality rate of the animals increased with the severity of malnitrition.On the basis of the findings it is belived that there is a synergic pathological effect of incontrollable inflammation and gut-originated infection especially in protein-deficient conditions.