氨茶碱增强犬膈肌功能作用

The effect of aminophylline to strenthen diaphragmatic function in dogs

采用双侧膈神经电刺激方法,测定Pdi-F曲线,结合EMGdi频谱分析,观测氨茶碱对犬正常和疲劳膈肌的作用。在静注氨茶碱(10、20mg/kg)后,Pdi-F显著增加,Pdi曲线左移,EMGdi频谱显著上升。提示治疗剂量氨茶碱具有增强犬膈肌肌力和恢复膈肌疲劳作用。

After the bilateral phrenic nerves of the dogs were stimulated,the effect of amino-phylline on the function of normal and fatigued diaphragm was observed with the determination of transdiaphragmatic pressure-stmulation frequency curve (Pdi-F).and the analysis of the power spectrum of diaphragmatic electromyogram (DMGdi) at spontaneous breathing.After the administration of 10 and 20 mg/kg of aminophylline ,the PDi pf the normal diaphragm was increased and that of the fatigued diaphragm recovered.The Pdi-F curve of the fatigued diaphragm was shifted to the left,and the central frequency,the medium frequency,and the high/low frequency ratio were markedly increased.It is concluded that aminophylline at the therapeutic dosage can imporve the generation of the strength and enhance the recovery of the fatigued diaphragm.