人发中7种微量元素与原发性肝癌关系的病例对照研究

Relationship between seven trace elements in hair and hepatocellular carcinoma: A case-control study

作者采用病例对照的方法,探讨陕西地区早期原发性肝癌与头发中锌、铜、铁、锰、铬、钼和硒含量的关系。单因素统计结果表明,肝癌组发锰和发铬含量明显高于对照组,肝癌组发锰为1.37±1.72ppm,对照组为0.74±0.56 ppm(P<0.05),肝癌组发铬为5.04±1.82 ppm,对照组为3.91±1.22ppm(P<0.05).钼和硒则明显低于对照组,肝癌组发钼含量为0.02±0.007 ppm,对照组为0.05±0.02 ppm(P<0.01);肝癌组发硒为0.57±0.19μg/g,对照组为0.70±0.33μg/g(P<0.05).而铜、锌、铁和铜/锌比值在两组无显著差异.Logistic多因素分析最终进入方程的元素为钼和硒,相对危险度(OR)分别为0.9225和0.1422,提示肝癌患者体内钼和硒水平降低,而其它5种元素变化不明显。

Forty-two patients with hepatocellular carcinoma (HCC)and controls from surgical wards in Xijing Hospital, matched for sex, age, occupation and socio-economic conditions, were studied to observe the relationship between seven trace element levels is in hair and HCC. All patients have been living in Shaanxi for twenty-five years or more. The result showed that manganese (Mn) and chromium (Cr) levels of hair in HCC were higher than in controls. The Mn level of hair is 1.37±1.72 ppm in HCC, and 0.74±0.56 ppm (P<0.05)in the controls. The Cr level is 5.04±1.82 ppm in HCC, and 3.91 ± 1.22 ppm (P<0.05) in the controls. However, the hair molybdenum (Mo) and selenium (Se) levels were lower in HCC than in the controls. The Mo level of hair in HCC is 0.02±0.007 ppm, that in the controls is 0.05±0.02 ppm (P<0.01). The Se level in HCC is 0.57±0.19μg/g, that in the controls is 0.70±0.33 μg/g, (P<0.05). There were not significant differences for hair cooper (Cu), zinc (Zn), iron (Fe) levels and Cu/Zn ratios between two groups. The data of the seven trace elements were analysed by the logistic regression and the results indicated that the Mo and Se were related to HCC. The odds ratios (OR)of Mo and Se levels were 0.9225 and 0.1422, respectively.The effects of them were not influenced by other elements. It was suggested that Mo and Se might be protective (actors for HCC.