肝硬变患者血浆胃动素浓度的变化

Preliminary study on plasma motilin level in patients with liver cirrhosis

作者应用特异的胃动素抗体,通过放射免疫测定法,测定了肝硬变患者40例和健康人52例血浆胃动素的含量。结果表明:肝硬变患者血浆胃动素含量平均为495.76±41.43 ng/L,明显高于正常人水平(381.17±19.23ng/L),两者有显著差异(P<0.01).而肝硬变患者中,肝功能越差,血浆胃动素水平越高,且28例腹水组血浆胃动素水平(554.21±55.01ng/L)高于12例无腹水组(359.37±23.12ng/L,P<0.05);8例并发肝肾综合征的患者的血浆胃动素水平(753.82±145.93ng/L)高于32例无肝肾综合征的患者(431.24±28.73ng/L,P<0.01)。作者认为,肝硬化患者血浆胃动素浓度增高,可能与肝脏灭活减少、门体分流、肾功能不全等有关。

Plasma motilin level was determined with specific motilin antibody by radioimmunoassay in 40 patients with liver cirrhosis and 52 normal subjects. The results showed that the average plasma motilin level in 40 cirrhotic patients was higher than that of the normal subjects (495.76±41.43 ng/L and 381.17±19.23 ng/L respectively, P<0.01). It is apparent that the plasma motilin level was increasingly elevated as the liver function getting worse. Average plasma motilin was 554.21 ±55.01 ng/L in 28 patients of liver cirrhosis with -ascites and 359.37±23.12 ng/L without ascites (P<0-05). Average plasma motilin was 753.82±145.93 ng/L in 8 patients with hepato-renal syndrome and 431.24±28.73 ng/L those without (P><0.01). It is suggested that the impaired inativation of motilin in the cirrhotic liver as well as the presence of portosystemic shunt and renal insufficiency may contribute to the high plasma motilin level in patients with liver cirrhosis.