摘要
中药地龙胶囊(912)是一种蚯蚓提取物的胶囊制剂.作者对食管癌331例和肺癌155例患者分别随机分为2组:放疗加912组(用药组)和单纯放疗组(对照组).所有病例均经细胞学或病理学确诊.服药剂量:早晚饭前各服1次,每次2~3粒(每粒含量为60mg),连服2月为1个疗程.治疗结果:与对照组相比,食管癌和肺癌用药组的完全缓解率(CR)和总缓解率(CR+PR)分别增加了9.7%(P<0.01)和9.6(P<0.05),10.6%(P<0.05)和13.5%(P<0.05).该药服用安全,对人体重要器官无明显毒副作用,16.7%的患者有恶心等轻度反应,但均能耐受。
Earthworm capsule is a preparation extracted from earthworm body in our laboratory. From 1986 to 1989, 486 patients with carcinoma of esophagus or lung were randomly divided into 2 groups, receiving radiotherapy alone (control group) or radiotherapy combined with earthworm capsules (treatment group) respectively. All patients were diagnosed pathologically or cytologically. In a two month treatment course, earthworm capsules were given orally twice a day. 2 -3 capsules each time, each capsule containning 60 mg extracted preparation. Compared with the control group, the CR rate and CR+PR rate in patients with carcinoma of esophagus treated with radiotherapy in combination with earthworm capsule increased 9.7% (P<0.01 ) and 9.6% (P<0.05), while in patients with carcinoma of lung, they increased 10.6% (P<0.05)and 13.5% (P<0.05 ) respectively. The earthworm capsule caused in the irritation alimentary tract, the patients displaying slight nausea and vomiting (16.7% in combination treatment group vs 10.0% in the control group). However, they could be alleviated when the capsule was taken after meal or with honey concomitantly. No deleterious effects on the heart, liver, kidney, skin, hematopoietic or nervous system were seen.
出处
《第四军医大学学报》
1992年第3期165-168,共4页
Journal of the Fourth Military Medical University
关键词
蚯蚓
提取物
食管肿瘤
肺肿瘤
earthworm extract
medicine, Chinese traditional
radiation sensitizing agents
esophageal neoplasms: lung neoplasms
radiotherapy