SCL基因在急性白血病患者中的表达及其意义

THE EXPRESSION OF SCL GENE IN ACUTE LEUKEMIA PATIENTS AND ITS SIGNIFICANCE

目的 :探讨 SCL 基因在急性白血病患者中的表达及其临床意义。方法 :应用 RT-PCR方法对 110例急性白血病患者不同时期 12 7份外周血标本中 SCL 基因的表达进行检测。结果 :在初治 /复发期、完全缓解期 (缓解时间 <6月 )及完全缓解后期 (缓解时间 >2年 )急性白血病中 SCL基因表达阳性率分别为 6 5 .9%、5 6 .3%及 2 0 .0 % ,在初治 /复发期与完全缓解后期间差异有显著性(P<0 .0 5 )。正常人外周血未检测到 SCL 基因表达。结论 :大多数急性白血病表达 SCL 基因 ,SCL 基因在急性白血病的发生中可能起一定的调节作用 。

Objective:To investigate the expression of SCL gene in acute leukemia (AL) patients and its clinical significance.Methods:SCL gene transcripts in 127 peripheral blood (PB) samples from 110 various stage cases with AL were detected by reverse transcription polymerase chain reaction (RT PCR).Results:The expression rates of SCL gene in untreated or relapsed,early stage of complete remission (CR) and late stage of CR cases with AL were 65.9 %,56.3 % and 20.0 % respectively,it was significantly higher in untreated or relapsed cases than that in late stage of CR cases ( P <0.05).SCL gene transcripts could not be detected in normal PB.Conclusion:The expression of SCL gene could be detected in the most cases with AL.SCL gene may play a regulatory role in the pathogenesis of AL and its expression can be used for detection of minimal residual disease.