摘要
作者用离体兔心灌注和SD大鼠在体心脏冠状动脉结扎,制造心肌缺血后再灌注两种模型.研究了六甲氧苄嗪(HMZ)对再灌注性心律失常(RA)的影响,同时探讨与氧自由基的关系.结果提示,HMZ4 mg/kg和灌流浓度16μmol/L能使RA的发生率明显降低;并能提高红细胞内超氧化物歧化酶(SOD)的活性.血浆脂质过氧化代谢产物丙二醛(MDA)含量由对照组浓度为2.6±0.4 nmol/L减少到1.8±0.2 nmol/L;还观察到具有剂量依赖性的负性频率作用.说明HMZ有较好的抗RA药理效应,其机理可能与降低心率和抑制自由基反应有关.
The experiment of rerirculating blood perfusion device showed that hexametazidine (HMZ) 16μmol/L could inhibit significantly the arrhythmias induced by ischemia and reperfusion, decrease the content of malondial-dehyde and improve superoxide dismutase activity of red blood cell in isolated rabbit hearts. In the experiment with coronary artery occlusion of rats, we discovered that HMZ 4 mgAg administered intravenously could also inhibit arrhythmias induced by reperfusion and reduce heart rate. The results indicate that HMZ can prevent the arrhythmias induced by ischemia and reperfusion. The mechanism may be related to the reduction of lipid peroxidation reaction.
出处
《第四军医大学学报》
1992年第6期463-466,共4页
Journal of the Fourth Military Medical University
关键词
六甲氧苄嗪
心律失常
超氧物歧化酶
hexametazidine
reperfusion arrhythmias
malondialdehyde
superoxide dismutase
