摘要
家兔10只,取出其窦房结-心房肌标本,用酒石酸锑钠(SAT)灌流后,起搏细胞动作电位幅值、O相平均去极速率及舒张期去极速率增加,动作电位时程(APD_(25)、APD_(50)、APD_(90)缩短;心房肌细胞动作电位幅值及收缩幅值增加,APD_(25)、APD_(50)、APD_(90)及收缩时程延长,心率增加:此外,还观察到各种心律失常现象。酒石酸锑钠(SAT)的上述作用可能与它使细胞内Ca^(2+)增高有关。
The effects of sodium antimony tartrate ( SAT)on the electrophysiological properties and contractions of sino-atrial node ( SAN ) and atrial preparation of rabbit were studied using floating glass microelectrode. It was found that SAT perfu-sion caused an increase in action potential amplitude ( APA ) and in phase O mean depolarization rate and diastolic depolarization rate: and a hortening in action potential durations ( APD25、 APD50、 APD90) of the pacemaker cell, and an increase in APA, contraction amplitude ( CA ) , contraction duration ( CD ) and heart rate (HR) ; and a significant prolongation in APD25, APD50, APD90 of the atrial cells. Various kinds of arrhythmia were also observed. The results suggest that SAT perfusion may increase the intracellular calcium level.
出处
《第一军医大学学报》
CAS
CSCD
1992年第1期28-30,共3页
Journal of First Military Medical University
关键词
心房肌
酒石酸锑钠
心律失常
sinoatrial node
heart atrium
sodium antimony tartrate
contrac-tion
action potentials
arrhythmia