膀胱移行上皮癌及其周围膀胱组织中T淋巴细胞和巨噬细胞的分布

Study on the infiltrating lymphocyte subsets in the tissue of bladder carcinoma

用免疫过氧化物酶技术和单克隆抗体技术观察了膀胱移行上皮痛及其周围组织中的淋巴细胞亚群。发现肿瘤和距肿瘤2cm的组织大多数没有或有散在T淋巴细胞和M+浸润,少部份有较多上述细胞浸润。肿瘤间质和粘膜固有层浸润多于肿瘤实质和粘膜上皮层;T_4细胞多于T_8细胞;远离肿瘤的膀胱组织免疫细胞浸润少,免疫细胞的浸润程度和肿瘤分期呈正相关;免疫细胞聚集部位未见肿瘤细胞坏死。

The change of lymphocyte subsets in the tissues of carcinoma and bladder around it was studied with immunoperoxidase technique and monoclonal antibodies to clarify the local immunocompetence in 25 cases of TCCB. The results showed that T lymphocytes and macrophages infiltrated no or sparsely in the major part of the tumors and bladder tissuses 2cm from them,but they infiltrated heavily in the minor part. The number of the above cells in the tumor stroma and lamina propria of the bladder mucosa was more than that in the tumor parenchyma and epithelial layer of the bladder mucosa. T4 cells was more numerous than T8 cells. There was only little infiltration of lymphocytes in the bladder tissue far from the tumor. The degree of lymphocyte infiltration was directly related to the stage of tumor. No necrosis of tumor was found in the lymphocyte infiltrated region.