鼻咽癌患者和EB病毒血清学阳性者外周血CD_4及CD_8细胞的变化

Change of CD_4 and CD_8 cells in nasopha-ryngeal carcinoma patients and Epstein-Barr virus seropsitive individuals

本文测定了鼻咽癌(NPC)患者和EB病毒(EBV)血清学阳性及阴性者T细胞亚群的变化。结果表明,这三组人群的CD_4^+细胞百分率分别为33.72±6.83,43.78±11.46和49.16±9.14;CD_8^+细胞百分率分别为31.26±5.64,43.88±10.69和35.74±8.53。各组之间相差有显著统计学意义。NPC患者和VCA-IgA抗体阳性者的CD_8/CD_4细胞比值下降。提示体内EBV激活和增殖与T调节细胞变化有关。

The immunefluorescent method was used to test the T subpopulations in the nasopharyngeal carcinoma patients ( NPC ) and the Epstein-Barr virus ( EBV ) se-ropositive individuals. The results showed that the percentage of the CD4 cells was 33.72±6.83, 43.78±11.46 and 49.16±9.14; of the CD8 cells was 31.26±5.64, 43.88±10.69 and 35.74±8.53 respectively in the three groups. The ratios of CD4 to CD8 cells was lowed in the NPC patients and EBV seropositive individuals. This suggests that the activation and proliferation of EBV in vivo are related to the number of CD4 and CD8 cells.