慢性乙型肝炎病人血清中游离白细胞介素2受体升高的意义

Significance of increased free interleukin 2 rece-ptor in sera of patients with chronic hepatitis B

应用放射免疫分析法测定慢性活动性肝炎(CAH)和慢性迁延性肝炎(CPH)病人及健康人血清中游离白细胞介素2受体(fIL2R)水平,CAH和CPH病人的cpm分别是2326±617及1277±397,健康人仅为343±213。结果发现:CAH和CPH病人血清中fIL2R水平均显著高于健康人(P<0.01);CAH病人血清中fIL2R水平高于CPH病人(P<0.01)。提示,慢性乙型肝炎病人血清中fIL2R水平升高可能与其免疫应答异常及炎症活动性有关。

Immunoradiometric assay was used to measure serum levels of free interleukin 2 receptor ( fIL2R ) in patient with CAH. CPH and normal individuals, the fIL2R levels represented by cpm were 2326±617 in CAH, 1277 ± 397 in CPH and 343 ± 213 in normal individuals. The results revealed that the serum fIL2R levels in CAH and CPH were significantly higher than those observed in normal individuals (P<0.01 ) . The difference between in CAH and in CPH was very significant (P<0.01 ) . The results suggested that increased fIL2R levels in serum may be correlated with the adnormal immune response and inflammatory activity of patients with chronic hepatitis B.