损毁面神经后核内侧区神经元胞体对呼吸节律的影响

Effects of chemical destruction of the medial region of nucleus retrofacialis on respira-tory rhythm

1％ procaine阻滞和电损毁面神经后核内侧区(mNRF)可消除动物节律性呼吸。红藻氨酸(Kainicacid)化学损毁mNRF,也引起动物不可逆性呼吸停止。结果提示,阻滞和电损毁面神经后核内侧区引起的呼吸停止是由于破坏了该区的神经元胞体所致。这些被破坏的神经元和呼吸节律的起源有关。

Experiments were performed on 32 rabbits of either sex. The animals were anesthetized with urethane and bivagotomized. The phrenic activities and intra-tracheal pressure were recorded as the indications of respiratory activity. After blockade of the medial region of nucleus retrofacialis ( mNRF ) with 1 % procaine, the rhythmic respiration was abolished. Microlesion of the mNRF with DC current ceased respiration. The bilateral chemical destruction of the mNRF neurons with Kainic acid produced irreversible abolishement of the respiratory rhythm. The results suggest that the effects of blockade or destruction of mNRF result from the destruction of the neuronal cell bodies, not of the fibers passing by. These neurons may play an important role in the generation of rhythmic respiration.