细支气管肺泡癌的光镜及电镜研究

Ultrastructural and pathological study of bronchiolovalveolar carcinoma

目的 :探讨细支气管肺泡癌的组织起源及亚型分类。方法 :选择符合WHO肺肿瘤组织学分型标准的细支气管肺泡癌 30例 ,进行光镜及电镜观察。结果 :30例细支气管肺泡癌 (其中 14例行电镜检查 )中 ,10例为粘液型 ,18例为非粘液型 ,2例为混合性粘液与非粘液细胞 (中间细胞 )型 ;电镜检查观察到粘液细胞 ,Clara细胞及Ⅱ型肺泡细胞的超微结构特征。结论 :细支气管肺泡癌可起源于粘液细胞、Clara细胞及Ⅱ型肺泡细胞 ,组织学分型宜分为粘液型、非粘液型及混合型 (中间细胞型 )

Objective: The histological origin and subtype classification of bronchioloalveolar carcinoma(BAC). Methods and results: 30 cases of BAC diagnosed according to the WHO rules were studied by light and electron microscopy.10 cases were mucinous type, 18 cases were non mucinous type, 2 case were mixed mucinous and non mucinous (indeterminate cell)type. Electron microscopic study showed the ultrastructural peculiarities of mucin cell, Clara cell and typeⅡpneumocytes. Conclusion: BAC can have different cytogenic origin: mucin cell, Clara cell and typeⅡpneumocytes. The histologically BAC contains mucinous type, non mucinous type and mixed type.